| 摘要 |
NEW MATERIAL:An imidazole derivative of formula I (R<1> is lower alkylthio, lower alkyl or phenyl; R<2> is H or lower alkyl; X is S or S=O; R<3>, R<4>, R<5> and R<6> are same or different H, halogen, lower alkyl, lower alkoxy, nitro, amino, trifluoromethyl, cyano, lower alkoxycarbonyl, carbamoyl, etc., substituted to arbitrary sites or adjacent groups thereof may form a ring such as 1,3- butadiene-1,4-diyl, trimethylene, etc.) and its acid addition salt. EXAMPLE:5-Methyl-2-methylthio-4-[[(2-naphthyl)thio]methyl]imidazole. USE:Useful as a preventive and remedy for gastric ulcer or duodenal ulcer, etc. PREPARATION:The compound of formula IV which is one of the compound of formula I can be produced e.g. by reacting the compound of formula II with the compound of formula III (Y is halogen).
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