发明名称 |
Enhancement of antigen immunogenicity. |
摘要 |
<p>A new method is described for eliciting IgG antibody response to proteins or synthetic peptides without the requirement for the use of adjuvants, thereby making it easier and safer to confer protection against pathogenic organisms. The antigen is coupled to a monoclonal antibody, specific for membrane determinants expressed on certain types of mamalian recipients cells, called antigen presenting cells. The monoclonal antibody acts as a "vector" or "delivery vehicle" for targeting foreign antigens onto such recipient cells. This targeting facilitates subsequent antigen recognition by helper T-cells, which are pivotal in helping the induction of antigen-specific IgG responses.</p> |
申请公布号 |
EP0245078(A2) |
申请公布日期 |
1987.11.11 |
申请号 |
EP19870304005 |
申请日期 |
1987.05.05 |
申请人 |
CONNAUGHT LABORATORIES LIMITED |
发明人 |
BARBER, BRIAN HAROLD;CARAYANNOTIS, GEORGE |
分类号 |
C12N15/02;A61K39/00;A61K39/385;A61K39/395;A61K47/00;A61K47/48;C07K1/22;C07K14/00;C07K16/00;C07K19/00;C12N15/00;C12P21/00;C12P21/08;C12R1/91 |
主分类号 |
C12N15/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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