| 摘要 |
PCT No. PCT/NL83/00014 Sec. 371 Date Dec. 7, 1983 Sec. 102(e) Date Dec. 7, 1983 PCT Filed Apr. 7, 1983 PCT Pub. No. WO83/03604 PCT Pub. Date Oct. 27, 1983.The invention relates to a process for preparing substituted polycyclo-alkylidene polycyclo-alkanes, such as substituted adamantylidene adamantanes, and the corresponding epidioxy compounds, in which polycyclo-alkylidene polycyclo-alkanes are halogenated with an N-halosuccinimide, tert.-butylhypohalite or sodium hypohalite/CH3COOH, the halogenation product is optionally subjected to a substitution reaction, and the substituted polycycloalkylidene polycyclo-alkanes are converted to the corresponding epidioxy compounds in a way known per se. Further, the invention relates to compounds of formula 44 <IMAGE> in which A and B represent alkylene radicals, which alkylene radicals may be attached to each other via an alkylene radical C, and R1 represents a substituent, which, in case of 4-eq.-R1-2,2'-adamantylidene adamantane cannot be chloro, hydroxy, oxo, D or a group of formula 1: <IMAGE> as well as to compounds of formula 45: <IMAGE> in which A, B and C are as defined above, and R2 is a substituent which, in case of 4-eq.-R2-2,2'-epidioxy-2,2'-adamantyl adamantane cannot be chloro or hydroxy. Compounds of formula 45 are useful as thermochemiluminescent labels and probes in the study of biological processes and in immuno-assays.
|
