发明名称 |
C-glycosidic adriamycin analogs |
摘要 |
Disclosed herein is a new procedure for preparing the C.1-2,4-pentadienyl derivatives of 2-deoxyhexopyranoses, as well as a new procedure for allylation of daunosamine. These methods are particularly useful for the preparation of intermediates in the synthesis of adriamycin C-glycosidic analogs which are useful anti-tumor agents. These methods provide the first enabling disclosure of methods to prepare these desired adriamycin and anthrocyclinone C-glycosidic analogs.
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申请公布号 |
US4705850(A) |
申请公布日期 |
1987.11.10 |
申请号 |
US19840674175 |
申请日期 |
1984.11.23 |
申请人 |
SRI INTERNATIONAL |
发明人 |
ACTON, EDWARD M.;RYAN, KENNETH J.;TRACY, MICHAEL |
分类号 |
C07D309/14;C07H15/244;C07H15/252;(IPC1-7):C07H7/02;C07H15/24 |
主分类号 |
C07D309/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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