ANTIBODY PREPARATION DIRECTED AGAINST NEOANTIGENS IN HUMAN C3 (COMPLEMENT FACTOR 3) AND THE USE AND MANUFACTURE THEREOF

摘要

Antibody preparation directed against an individual neoantigen in the C3b region of human C3, and the use and production thereof. The preparation is characterized by immunnochemically reacting with (a) antigenic determinants in the C3b region of the alpha or beta chain of denatured human C3 in which the disulfide bonds have been reduced, but not with (b) human native C3. The use comprises immunochemically binding the preparation to C3 fragments, especially C3 fragments bound to immune complexes. The production encompasses the raising of an immune response containing the antibodies and selecting from said response the antibodies having the specificity given above.