摘要 |
<p>NEW MATERIAL:A compound of formula I [X1 and Y1 are group of formula II (n is 0, 1, 2 or 3); Z1 is H or group of formula III (m is 0, 1, 2 or 3); W is H or OH; R1 and R2 are H or 1-10C alkyl]. EXAMPLE:6-Butyl-3-(beta-D-deoxyribofuranosyl)-2-oxopyrrolo[2,3-d]pyrim idine. USE:A fluorescent probe for clarifying the relationship between the structure and function of proteins or nucleic acids. PREPARATION:The compound of formula I can be produced e.g. by protecting hydroxyl group of 5-iododeoxycytidine of formula IV which a siloxane compound, reacting with 1-hexyne to obtain 5-(1-hexynyl)-2'-deoxycytidine of formula V, cyclizing the compound to a pyrimidine compound and removing protecting groups from hydroxyl group and amino group of the produced pyrimidine compound.</p> |