| 摘要 |
PURPOSE:A drug effective for treating medullary leukemia, containing a human granular colony stimulation factor as an active ingredient. CONSTITUTION:A remedy for medullary leukemia (G-CSF for short) having the following physical and chemical properties as an active ingredient. Molecular weight: 19,000+ or -1,000 measured by sodium dodecyl sulfate-polyacrylamide gel electrophoresis method. Isoelectric point: having at least one of three electric points of pI 5.5+ or -0.1, pI 5.8+ or -0.1 and pI 6.1+ or -0.1. UV: having maximum absorption at 280nm and minimum absorption at 25nm. Amino acid sequence: having amino acid sequence shown by formula I from N end to 21-th residue. The human G-CSF contains a polypeptide shown by formula II (X is Leu. etc.; n is 0 or 1) or part thereof. The remedy has both increasing effects on peripheral mature neutrophil of patient of medullary leukemia and macrobiotic effects and is effective for medullary leukemia.
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