| 摘要 |
NEW MATERIAL:An artificially modified lipid which is substituted at a part of lipid with a chromophore. EXAMPLE:A compound expressed by formula I. USE:Analysis of lipid-protein interaction in a membrane of organism, capable of measuring at lower concentration than NMR or ESR with good stability. PREPARATION:For example, a lipid is first hydrolyzed with an alkali to convert an ester residue in the lipid into hydroxyl group, then reacted with a acylating agent, alkylating agent, etc., having a chromophore [example; formulae II and III (R<1> represents 1-15C aliphatic group; X and Y represent halogen atom, alkyl, cyano, etc.; m and n are 0-4; X represents 1-20C alkyl, cyano, halogen, atom, etc.; R<3> represents 1-20C alkyl; l and n are 0-12; a is 0 or 1), etc.]. The reaction is normally carried out at room temperature -100 deg.C, if necessary, in an inert solvent such as chloroform, etc.
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