Peptides having ANF activity.

摘要

Novel peptides having potent natriuretic activity are disclosed with the following amino acid sequence: <CHEM> wherein X is Ile or Met, A is the N-terminal group of Cys, Ser, Ser-Ser, Arg-Ser-Ser, Arg-Arg-Ser-Ser, Leu-Arg-Arg-Ser-Ser or Ser-Leu-Arg-Arg-Ser-Ser and B is the C-terminal group of Cys, Asn, Asn-Ser, Asn-Ser-Phe, Asn-Ser-Phe-Arg, or Asn-Ser-Phe-Arg-Tyr, provided one optically active amino acid residue is substituted by Ala or Abu ( alpha -amino-butyric acid), or one Gly is substituted by Abu, and the amides, lower alkyl esters and the physiologically acceptable metal salts and acid addition salts thereof. A disulfide bond between the two cysteine residues may be present or absent. When the amino acid in positions 12 or 28 is other than Cys, the peptide is linear rather than cyclic.