| 摘要 |
PURPOSE:To obtain the titled compound useful as an intermediate for pharmaceuticals, in high yield and reproducibility, by carrying out electrolytic reaction of uracil and trifluoroacetic acid in the presence of copper ion using a platinum electrode. CONSTITUTION:Uracil having a concentration of 0.001-1mol/l and a copper salt (above all easily handleable inexpensive copper sulfate, etc.) are dissolved in trifluoroacetic acid optionally using a supporting electrolyte and a solvent. The solution is electrified using a platinum electrode at a current density of 1-500mA/cm<2> controlling the terminal voltage to 5-20V preferably under ice-cooling or at room temperature for 1-100hr to obtain the objective compound. EFFECT:Absolutely no problems occur on continuous operation, separation and purification. USE:An intermediate for the production of pharmaceuticals such as 5- trifluoromethyluridines, 5-trifluoromethyldeoxyuridines, etc., useful as a carcinostatic agent or antiviral agent. |
