Transdermal therapeutic system having improved delivery characteristics

摘要

A transdermal therapeutic system using a subsaturated matrix is provided having improved approved release characteristics. Reinforcing means preferably in the form of a fabric are embedded in the upper surface of the subsaturated matrix. At least a portion of the reinforcing means is selected such that the active agent to be delivered to the skin has a solubility, Cr therein which is lower than the initial solubility Co of the agent in the matrix. In addition, the relationship between the diffusion coefficients of the agent in the matrix Dm and the portion of reinforcing means Dr and the solubilities is given by the relationship: DrxCr