| 摘要 |
<p>This invention provides a benzene-fused heterocyclic compound of the formula: <IMAGE> (I) wherein R1 is halogen, nitro, amino, hydroxy, lower alkyl, lower alkoxy or acylamino, X is -S-, <IMAGE> n is an integer of 1 or 2 and A is a group of the formula: <IMAGE> in which R2 is hydrogen, lower alkyl, lower alkynyl, carboxy(lower)alkyl or protected carboxy(lower)alkyl, or pharmaceutically acceptable salts thereof. This compound possesses diuretic, uricosuric, and vasodilative activities and therefore is useful as a diuretic agent, uricosuric agent and anti-hypertensive agent. This invention further provides processes for the preparation of this compound and pharmaceutical composition comprising compound of the above formula.</p> |
