| 摘要 |
<p>The invention relates to compounds of formula (I) <CHEM> wherein Im represents a imidazolyl group of formula: <CHEM> R<1> represents a hydrogen atom or a C1-6 alkyl, C3-6 alkenyl, C3-10 alkynyl, C3-7 cycloalkyl, C3-7 cycloalkylC1-4alkyl, phenyl or phenylC1-3alkyl group; R2 represents a hydrogen atom or a C1-6 alkyl, C3-6 alkenyl, C3-7 cycloalkyl, phenyl or phenylC1-3alkyl group; A-B represents the group R<3>R<4>C-CH2 or R<3>C=CH; R<3> and R<4>, which may be the same or different, each represents a hydrogen atom or a C1-6 alkyl group; one of the groups represented by R<5>, R<6> and R<7> represents a hydrogen atom or a C1-6 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, phenyl or phenylC1-3alkyl group, and each of the other two groups, which may be the same of different, represents a hydrogen atom or a C1-6 alkyl group; and physiologically acceptable salts and solvates thereof. The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting.</p> |
