| 摘要 |
The invention provides novel imidazoquinolines, processes for their preparation and pharmaceutical compositions containing them. The compounds have Formula I <IMAGE> (I) wherein A is a C1-C4 straight or branched alkylene chain which may be saturated or unsaturated, B is a C2-C4 straight or branched alkylene chain which may be saturated or unsaturated, R1 and R2 are the same or different and are hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxyalkyl, C1-6 hydroxyalkyl, hydroxy, halogen, nitro, carboxy, carboxylic lower alkyl ester, carbamoyl, carbamoyloxy, cyano, loweralkanoyl, lower alkanoylamino or trifluoromethyl, Het is a heterocyclic group chosen from imidazolyl, imidazolinyl, benzimidazolyl, thiazolyl, thiazolinyl, quinolyl, piperidyl, pryidyl, benzothiazoly and pyrimidyl, any of which heterocyclic groups may be substituted, and x is 0 or 1, and pharmaceutically acceptable salts thereof. The compounds are anti-ulcer/anti-secretory agents.
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