| 摘要 |
Title compds. I [R1=H, metal salts; R2=H, acetoxymethyl, (1methyl-1H- tetrazol-5-yl) thiomethyl, etc. , useful as an antimicrobial agent, are prepd. Thus, a mixt. contg. 5.44g 7aminocephalosporanic acid, 100ml H2O, 40ml N,N-dimethyl-foramide, and 2.4g NaHCO3 is stirred for 10min, cooled to 10≦̸C, and treated with 7.87g 1-[α -syn-methoxyimino-α-(2-amino-thiazol-4-yl)acetyl -benzotriazol-3-oxide in 40ml N,N- dimethyl formamide. After 4h stirring, the reaction mixt. is reacted with 150ml ethylacetate twice to give 7.98g 7-[[2-2-(2-amino-thiazol-4- yl)-2-synmethoxyimino acetamido! cephalosporanic acid.
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