| 摘要 |
A process for protecting the 2'-hydroxyl of a nucleoside, which can then be used in the chemical synthesis of polyribonucleotides, comprising the reacting of a protected nucleoside of formula I <IMAGE> wherein B is a nucleoside heterocyclic base and R' is a hydroxyl-protecting group, with 1-N-aryl-4-alkoxy-1,2,5,6-tetrahydropiperidine of formula II <IMAGE> wherein Ar is an aryl group possessing an electron-withdrawing substituent which renders said protecting group acid labile and R is C1-C4 alkyl, in the presence of an acid catalyst and a solvent to yield the compound of formula II below: <IMAGE> |
