| 摘要 |
<p>A process for the linking of either aspartate or glutamate radicals to the N-terminal of an amino acid or derivative thereof or to the N-terminal residue of a peptide. The process is applicable for all amino acids with the exception of proline and hydroxy-proline and involves reacting an aspartate or glutamate radical of formula (I), in which n is 1 or 2, B1 is any group capable of forming an ester linkage, B2 is any group capable of forming an ester linkage and cleavable by a thiol proteinase and X is an aliphatic or aromatic hydrophobic group, with an amino acid derivative or peptide in the presence of a thiol proteinase.</p> |
