PROSTAGLANDINS

摘要

Novel compounds have the formula (I) the letters a and b indicating in each case the points of attachment of the substituents R<1> and CV(R<2>)-NV'R, respectively; R<1> is a group -(CH2)b-(A)a-(CH2)c-B-CH2-CO2R' in which A and B are each separately oxygen or sulphur, a is 0, b is 0 and c is an integer from 3 to 10, or a is 1, b is 0 or an integer from 1 to 7 and c is an integer from 2 to 9 with the sum of b and c being from 2 to 9, and CO2R' is a carboxy group or an amide, ester or salt derivative thereof; V and V' either each separately is hydrogen or together are the second bond of a carbon-nitrogen double bond; R<2> is hydrogen, an aliphatic hydrocarbon group or an aliphatic hydrocarbon group substituted by an aromatic group directly or through an oxygen or sulphur atom; and R is a group -OR<3>, -OR<4>, -D-R<3>, -N=R<5> or -NW.G.W' in which D is -NH-, -NH.CS-, -NH.CO-, -NH.CO.CH2N(R<6>)-, -NH.SO2-, -NH.CO.NH-, -NH.CS.NH-, -NH.CO.O-or -NH.CS.O-, G is -CO- or -CS- and W and W' together are a group -(CH2)d- in which d is 3, 4, or 5, R<3> is an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by one or more aromatic groups directly or through an oxygen or sulphur atom, R<4> is an aliphatic hydrocarbon group which is substituted through an oxygen atom by an aliphatic hydrocarbon group which is itself substituted directly by one or more aromatic groups, R<5> is an aliphatic hydrocarbon group, an aromatic group in which the pi -electron system is not fully delocalised over the entire ring system, or an aliphatic hydrocarbon group substituted by one or more aromatic groups directly or through an oxygen or sulphur atom, and R<6> is hydrogen, an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by one or more aromatic groups directly or through an oxygen or sulphur atom. The compounds are of value for use in pharmaceutical compositions particularly in the context of the inhibition of thromboxane activity.