发明名称 |
IMPROVED MANUFACTURE OF MACROLIDE DERIVATIVE |
摘要 |
This invention provides an improvement in the process for preparing C-20-amino-substituted derivatives of the macrolide antibiotics of the tylosin type by reductively aminating the C-20 aldehyde group in the parent antibiotic. The improvement comprises using formic acid as the reducing agent. The new process is less expensive and more amenable to scale-up than previously used processes, but is still selective. |
申请公布号 |
JPS62240681(A) |
申请公布日期 |
1987.10.21 |
申请号 |
JP19870075752 |
申请日期 |
1987.03.26 |
申请人 |
ELI LILLY & CO |
发明人 |
EDEII BUIIPIN TAO;JIEFURII TOOMASU BUISENJI |
分类号 |
C07H5/00;C07D407/14;C07H15/00;C07H17/08 |
主分类号 |
C07H5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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