Macrolide compounds.

摘要

Compounds of the formula <CHEM> [wherein R<1> represents a methyl group; R<2> represents a methyl group R<3> represents a methyl, ethyl or isopropyl group; and -A- represents a ring which is either <CHEM> (where R<4> is a hydroxy or methoxy group and R<5> is a hydrogen atom or R<4> and R<5> together with the carbon atom to which they are attached represent a group C=0); or when -A- represents ring (ii) wherein R<4> and R<5> together with the carbon atom to which they are attached represent a group C=0 then R<2> may also represent an aldehydo group; or R<2> represents a hydroxymethyl group and -A- represents <CHEM> (where R<6> represents a hydrogen atom or a hydroxy group); <CHEM> (where R<7> is a hydroxy or methoxy group and Z represents either a group CHOH or a group C=0); or R<1> represents a hydrogen atom and <CHEM> (where R<8> is a hydroxy or methoxy group); with the provisos that when R<2> represents a methyl group and R<4> represents a methoxy group then R<3> cannot represents a methyl or isopropyl group and when R<2> represents a hydroxymethyl group and R<6> represents a hydroxy group then R<3> cannot represent a methyl group. Compounds of the invention have antiparasitic activity.