PROCESSO PARA A PREPARACAO DE AMIDAS DE ACIDOS 1,2,3,4,,6,7,12,12B-OCTAHIDRO-INDOLO{2,3-A}-QUINOLIZIN-1-IL-ALCANOCARBOXILICOS E SEUS SAIS DE ADICAO DE ACIDO TERAPEUTICAMENTE UTEIS E DE COMPOSICOES FARMACEUTICAS QUE OS CONTEM

摘要

The invention relates to new 1,2,3,4,6,7,12,12b-octahydroindolo[2,3,-a]quinolizin-1-yl-alkanecarbox ylic acid amides of the formula (I), (I) wherein R1 and R2 stand independently for a hydrogen or halogen atom, or a hydroxyl, nitro or C1-4 alkoxy group; R3 and R4 stand independently for a hydrogen atom or a C1-4 alkyl group; R5 and R6 stand independently for a hydrogen atom, C1-8 alkyl group, C3-8 alkenyl or cycloalkyl group, aryl or aralkyl group, heteroaryl or heteroaralkyl group containing oxygen, nitrogen or sulphur atom, all these groups being optionally substituted; or R5 and R6together form an optionally substituted C2-8 alpha , omega -alkylene group, wherein one carbon atom may optionally be replaced by an oxygen or nitrogen atom; and G means a C1-4 straight chained alkylene group, as well as to their therapeutically suitable acid addition salts and pharmaceutical compositions containing these compounds. The compounds of the formula (I) have valuable therapeutic properties, namely vasodilatory, spasmolytic, antiarrhythmic and gastrocytoprotective effects. The gastrocytoprotective effect is particularly important.