MUTANT HUMAN T CELL LINE PRODUCING IMMUNOSUPPRESSIVE FACTOR AND METHOD FOR OBTAINING SUCH MUTANTS

摘要

MUTANT HUMAN T CELL LINE PRODUCING IMMUNOSUPPRESSIVE FACTOR A stable mutant human T cell line is disclosed which secretes a high titer suppressor inducer factor. This suppressor inducer factor in turn induces production of a T cell suppressor factor which suppressed mitogen-induced T cell proliferation at high dilution. Also disclosed is a general method for mutating lymphoblastoid cell lines to yield mutants secreting enhanced levels of lymphokines.