| 摘要 |
PURPOSE:To obtain a thermally stable fluorophenol useful as an intermediate for drugs, agricultural chemicals, liquid crystal compounds, etc., by treating a crude fluorophenol with a reducing agent in production process or after production. CONSTITUTION:A fluorophenol shown by the formula (X1 and Z2 are H, Cl, F or Br and at least one is F; Y is H, Cl or Br; Z is amino or nitro when X1 is Cl, X2 is F and Y is H and Z is H in other cases) is treated with a reduc ing agent to stabilize the fluorophenol thermally. A metallic reducing agent, a H2 gas in the presence of a catalyst for hydrogenation, phosphine, phosphite, sulfide, etc., except reducing agents which can not be thermally used are used as the reducing agent and the amount of the reducing agent used is 0.5-30mol% based on the fluorophenol. Addition of protecting agent is further effective in order to protecting materials of reactor from the actions of a decomposition inhibitor (e.g. alkylamine) of the fluorophenol and hydrofluoric acid.
|
