| 摘要 |
<p>Pyrazolotriazine compounds of the formula: <CHEM> wherein R<1> is OH or alkanoyloxy; R<2> is H, OH, or SH; R<3> is (1) unsaturated N- or S-containing heterocyclic group optionally having 1-2 substituents of halogen, nitro or phenylthio, (2) naphthyl, (3) phenyl optionally having 1-3 substituents of (i) alkyl, (ii) phenyl, (iii) alkoxycarbonyl, (iv) cyano, (v) nitro, (vi) alkoxy, (vii) phenylalkoxy (viii) phenylthio-alkyl, (ix) phenoxy, (x) <CHEM> (R is alkyl, halo-substituted alkyl, phenyl optionally having 1-3 substituents, or pyridyl, and l is 0, 1 or 2, (xi) halogen, (xii) phenylalkyl, (xiii) carboxy, (xiv) alkanoyl, (xv) benzoyl optionally having 1-3 substituents, (xvi) amino, (xviii) OH, (xviii) alkanoyloxy, (xix) <CHEM> said compounds having a xanthine oxidase inhibitory activity and are useful for the prophylaxis and treatment of gout.</p> |
