| 摘要 |
NEW MATERIAL:A compound shown by formula I (R is H, halogen, alkyl, alkoxy or amino; R<1> is H, alkyl, alkenyl, cycloalkyl, phenyl, phenylalkyl, naphthyl, acyl or aloxycarbonyl; Z is O or S; Y is 2-5C alkylene; R<2> and R<3> are H or methyl) and an acid addition salt thereof. EXAMPLE:3-(3-Ethylthioureido)-1-[2-(2,2,6,6-tetramethylpiperidino) ethyl]indolin-2- one. USE:A remedy for gastric ulcer and duodenal ulcer of mammals including human. Showing to important side effect even in high dose. PREPARATION:A compound shown by formula II is reacted with an equimolar amount or a little excess amount of an iso(thio)cyanate derivative shown by formula III (R<4> is R<1> except H) in an inert solvent to give a compound shown by formula I wherein R<1>not equal to H. |
