Products and methods for treatment of cancer

摘要

Disclosed are compositions for the treatment of cancer, such as lymphomas and solid tumors, methods of producing these compositions, and methods and regimens in using these compositions in the treatment of hosts having cancer. The compositions are (1) tumor immune preparations which can be prepared by acidification or alkalinization of an enriched immunoglobulin effluent from forced flow electrophoresis of plasma from a normal or a tumor bearing host, (2) tumor immune globulin which can be prepared by acidifying a Cohn gamma globulin fraction from a normal or a tumor bearing host, (3) protein A-IgG preparations which can be prepared by perfusion of plasma over protein A from staphylococcus aureus Cowans I and precipitating the complex or by incubating protein A and purified IgG or IgG in plasma, (4) tumor immune plasma preparations which may be prepared by acidification of plasma from normal or tumor bearing hosts, and (5) zymosan activated plasma which can be prepared by incubating plasma with zymosan and then removing the zymosan. Infusing of the compositions alone or in combination with each other and with various chemotherapeutic agents has resulted in tumoricidal reactions, objective anti-tumor effects, and sustained tumor regressions.