发明名称 |
7-amino-3-propenylcephalosporanic acid and esters thereof |
摘要 |
This invention provides novel cephalosporin intermediates, 7 beta -amino-3-[(Z)-1-propen-1-y1]-3-cephem-4-carboxylic acid and esters thereof having the general formula <IMAGE> wherein the configuration of the 3-propenyl group is Z sometimes referred to as cis- and R is hydrogen or a conventional carboxy-protected group, or a physiologically hydrolyzable esterifying group, and acid addition salts thereof and the metal salts of the foregoing substance wherein R is hydrogen. These compounds are useful as intermediates for preparation of orally active cephalosporins.
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申请公布号 |
US4699979(A) |
申请公布日期 |
1987.10.13 |
申请号 |
US19860843537 |
申请日期 |
1986.03.25 |
申请人 |
BRISTOL-MEYERS COMPANY |
发明人 |
HOSHI, HIDEAKI;OKUMURA, JUN;NAITO, TAKAYUKI;ABE, YOSHIO;ABURAKI, SHIMPEI |
分类号 |
A61K31/545;C07D501/18;C07D501/22;(IPC1-7):C07D501/22 |
主分类号 |
A61K31/545 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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