| 摘要 |
PURPOSE:To provide an enteric capsule composed of a core part obtained by dissolving or dispersing an enteric active component in a liquid substance and a wall membrane composed of a hardened oil having a melting point higher than body temperature, resistant to disintegration in mouth and stomach and easily disintegrating first in the intestine. CONSTITUTION:An enteric active component such as bifidus bacteria or a drug absorbable through intestinal wall is dissolved or dispersed in a liquid substance such as water, liquid oil or fat, alcohol or their emulsion, etc., and the solution or dispersion is used as a core-forming substance. The core-forming substance is encapsulated with a wall-membrane-forming substance composed of a hardened oil having a melting point higher than body temperature. The obtained capsule is resistant to disintegration in mouth or stomach in the case of oral administration and the lowering of the activity of the active component by the action of gastric juice or an enzyme of gastric juice can be prevented. It is easily disintegrated first in the intestine to enable effective utilization of the active component in the intestine. The encapsulation can be easily carried out by conventional method.
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