| 摘要 |
<p>7-oxoprostacyline derivatives of Formula (I) wherein R1 is the residue OR3, in which R3 can be hydrogen or possibly alkyl substituted by halogen, phenyl, C1-C4-alkoxy or C1-C4-dialkylamino with 1-10 C atoms, or the residue NHR4 in the form of an alkanoyl or alkane sulphonyl residue each with 1-10 C atoms; W is a hydroxy methylene or a group (II), in which the OH group may be esterified with a benzoyl or alkane acid residue with 1-4 C atoms or etherified with a tetrahydropyranyl, tetrahydrofuranyl, (C1-C4 alkoxy)-C1-C4-alkyl or tri-(C1-C4-alkyl)-sylyl residue, whereby the free OH-group can be in the α or β position; D is a straight-chain or branched alkylene group with 1-5 C atoms; R2 is a straight-chain or branched alkyl group with 1-6 C atoms; R5 is a hydroxygroup, which can be esterified with an alkane acid residue with 1-4 C atoms or etherified with a tetrahydropyranyl, tetrahydrofuranyl, (C1-C4-alkoxy)-C1-C4-alkyl or tri(C1-C4-alkyl) residue; X is an oxygen atom or the -CH2- residue and, if R3 is hydrogen, their salts with physiologically compatible bases, process for their production and their use as medicaments.</p> |
