| 摘要 |
Novel 4-hydroxy-3-quinoline-carboxamides of the formula <IMAGE> I wherein X is in the 5,6,7 or 8-position and is selected from the group consisting of hydrogen, halogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 4 carbon atoms, -CF3, -OCF3 and -SCF3, R1 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, R2 is selected from the group consisting of thiazolyl, 4,5-dihydro-thiazolyl, pyridinyl, oxazolyl, isoxazolyl, imidazolyl, pyrimidinyl and tetrazolyl, all optionally substituted with alkyl of 1 to 4 carbon atoms and phenyl optionally substituted with at least one member of the group consisting of -OH, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, -CF3, -NO2 and halogen R3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and aryl, R4 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and aryl, R5 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and <IMAGE> R5' is selected from the group consisting of alkyl of 1 to 4 carbon atoms and aryl and their non-toxic, pharmaceutically acceptable acid addition salts and salts with non-toxic, pharmaceutically acceptable bases having very good analgesic activity and a non-negligible anti-inflammatory activity and novel intermediates. |
