2-alkoxy-N-(1-azabicyclo¬2.2.2 -oct-3-yl) benzamides and thiobenzamides in the alleviation of emesis caused by non-platinum anticancer drugs

摘要

Compounds for controlling emesis caused by non-platinum anti-cancer drugs such as 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides have the formula wherein X is oxygen or sulphur; R1 is a loweralkyl group; and R2 represents hydrogen, halo, 4,5-benzo, methylsulphony, loweralkoxy or amino group and n is 1 or 2, and the pharmaceutrically acceptable acid addition salts thereof.