| 摘要 |
Compounds of formula R1CO-NH-CH(R2)-CONH-CH(R3)-X [wherein: R1 represents alkyl having an alpha -amino or protected alpha -amino substituent and an aryl, heterocyclic or heterocyclic-dithio substituent; R2 represents a variety of aliphatic and cycloaliphatic hydrocarbon groups, which may be substituted; R3 represents isobutyl, sec-butyl, benzyl or (C3-C8 cycloalkyl)methyl; and X represents a group of formula -CH(-A-R4)-Y (in which: A represents a single bond or an alkylene group; R4 represents a carboxy group; a protected carboxy group, a carbamoyl group, an N-substituted carbamoyl group, a carbazoyl group, an N-substituted carbazoyl group or an acyl group; and Y represents a hydroxy group, a mercapto group or a formyl group), or a group of formula -P(O) (R5)-OH (in which R5 represents a substituted alkyl group having at least one substituent selected from carboxy groups, protected carboxy groups, N-substituted carbamoyl groups, carbazoyl groups, N-substituted carbazoyl groups, C2-C7 aliphatic carboxylic acyl groups and aromatic carboxylic acyl groups)]; and their salts are renin inhibitors, which may be used in the treatment of angiotensin-induced hypertension.
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