(N-SUBSTITUTED PHENYL)UNSATURATED ACID AMIDE DERIVATIVE, PRODUCTION THEREOF AND 5-LIPOXYGENASE INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT

摘要

NEW MATERIAL:A compound shown by formula I [X is single bond, CHR<4>-CHR<5> (R<4> and R<5> are H or alkyl), trans CR<4>=CR<5> or CidenticalC; R<1> is H, alkyl, OH or phenyl; R<2> is COOH, 1H-tetrazol-5-yl, SO3H, group shown by formula II (Y is 0 or S: m is 1-4), etc.; R<3> is H, halogen, alkyl, etc.; group shown by formula III is cis CH=CH or CidenticalC; n is 6-8] or a salt thereof. EXAMPLE:(2E,11Z,14Z)-N-(3-Carboxyphenyl)-eicosa-2,1,1,14-trieneamide. USE:A 5-lipoxygenase inhibitor. PREPARATION:For example, a compound shown by formula IV and a compound shown by formula V (R<2a> is R except group shown by formula II) are subjected to amide bond-forming reaction to give a compound shown by formula I.