N-Methyl tri:fluoro:methyl-phenoxy phenyl-propylamine prepn.

摘要

N-Methyl 3-(p-trifluoromethyl phenoxy) 3-phenyl propylamine is made by (a) reaction of p-trifluoromethyl phenol with a molar equiv. of a cpd. of formula (I), in which P is a protective gp., in alcoholic medium in presence of NaOH or KOH at 60-100 deg.C and (b) removal of P in an inert solvent in acid medium at from 20 deg.C to reflux temp..