FOERFARANDE FOER FRAMSTAELLNING AV TERAPEUTISKT ANVAENDBARA 6- -(D-2-AMINOFENYLACETAMIDO)PENICILLANOYLIOXIMETYL -6'- -(HYDROXIMETYL)PENICILLANAT-1',1'-DIOXID OCH 6- -/D-2-AMINO-2-(P- HYDROXIFENYL)ACETAMIDO/PENICILLANOYLOXIMETYL-6'- -(HYDROXIMETYL)PENICILLA- NAT-1,1'-DIOXID SAMT MELLANPRODUKTER SOM ANVAE

摘要

Novel bis-Esters of 1,1-alkanediols with 6-beta(hydroxymethyl)penicillanic acid 1,1-dioxide and 6-betaacylaminopenicillanic acids are useful as antibacterial agents. Novel intermediates useful for the preparation of these compounds include: haloalkyl, alkylsulfonyloxyalkyl and arylsulfonyloxyalkyl esters of 6-beta-(hydroxymethyl)penicillanic acid and its 1-oxide and 1,1-dioxide; 6-beta-aminopenicillanoyloxyalkyl and 6-beta-(N-protected-D-2-amino-2-phenylacetamido and 2-[4-hydroxyphenyl]acetamido) penicillanoyloxyalkyl esters of 6-beta-(hydroxymethyl)penicillanic acid 1,1-dioxide; and haloalkyl, alkylsulfonyloxyalkyl and arylsulfonyloxyalkyl esters of the 6-bromo-6-(hydroxymethyl)penicillanic acids.