Process for the enzymatic resolution of racemic 2-amino-1-alkanols.

摘要

A process for the enzymatic resolution of racemic 2-amino-1-alkanols having formula (I): <CHEM> wherein R represents a C1-C8 alkyl group, comprises the asymmetric enzymatic hydrolysis of racemic (R,S) N-alkoxycarbonyl ester derivatives of said racemic 2-amino-1-alkanols (I) having formula (II): <CHEM> wherein R'' has the same meaning as R and R' represents a C1-C8 alkyl group or a benzyl group, in the presence of an enzyme, preferably a lipase capable of hydrolyzing selectively (asymmetrically) isomer (R) of ester (II), leaving unaltered isomer (S), whereafter the usual separation and hydrolysis of the products of the enzymatic hydrolysis to the corresponding separated (R) and (S) 2-amino-1-alkanols having formula (I) is carried out. The obtained optically active 2-amino-1-alkanol compounds may be used as intermediates for the production of biologically active products.