DERIVATIVES OF 4-OH QUINOLINE CARBOXYLIC ACID SUBSTITUTED AT POSITION 2 BY A DIHYDROXYLATED GROUP POSSIBLY ETHERIFIED OR ESTERIFIED,THE PROCESS AND THE INTERMEDIATES FOR THEIR PREPARATION,THEIR APPLICATION AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM

摘要

Compounds of formula (I): in which X at 5, 6, 7 or 8 is H, halogen, (C1-5) alkyl, (C1-4) alkoxy, -CF3, -SCF3, -OCF3, R1 is phenyl optionally substituted by at least OH, (C1-5) alkyl, (C1-4) alkoxy, CF3, NO2, halogen or a heterocyclic radical optionally substituted by a (C1-4) alkyl radical, R2 and R3 which are identical or different are H, (C1-4) alkyl, aryl, -C(:O)-R5, R5 being (C1-4) alkyl or aryl. R4 is H, (C1-4) alkyl or aryl, and their addition salts with acids and bases.