| 摘要 |
NEW MATERIAL:A compound expressed by formula I {A represents (1-3C alkyl-substituted) 1,3-propylene; Y represents Y1 when either one of X1 and X2 represents H and the other represents nitro, halogen atom or trifluoromethyl; Y1 represents 13-20C alkyl, formula II (R1 represents 1-3C alkyl; D represents 2-6C alkylene), -D-N(R2)2 [R2 represents (methyl-substituted)cyclopentyl, etc.] etc.; Y represents Y1 or Y2 when formula III represents formula IV; Y2 represents formula V (R3 represents alkyl substituted by aromatic group); Y represents Y1, Y2 or Y3 when formula III represents formula VI, etc.; Y3 represents formula VII (R4 and R5 represent 1-6C alkyl, etc.)}. EXAMPLE:2-(N-(1-Indanyl)-N-methyl)amino ester of 5-(2,2-dimethyl trimethylenedioxyphosphinyl)-2,6-dimethyl-4-(3-nitropheynyl-)-1,4-dihy dropyridine- 3-carboxylic acid. USE:An oral antihypertensive agent. PREPARATION:A compound expressed by formula VIII is reacted with a com pound expressed by formula IX. |
