FOERFARANDE FOER FRAMSTAELLNING AV 1,1-DIOXOPENICILLANOYLOXIMETYL-6-(D-2-AMINO-2-FENYLACETAMIDO)PENICILLANAT SAMT EN MELLANPRODUKT SOM ANVAENDS I FOERFARANDET.

摘要

Compounds of the formula wherein R<1> is H or HO; Y and Z are each Cl, Br or I, or Y is H and Z is Cl, Br or I; Q is N3 or NHCO2CH2C6H4R<4> where R<4> is H, Cl, Br, NO2, CH3 or OCH3; a process for their use in production of the valuable antibacterial agents 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanate and 1,1-dioxopenicillanoyloxymethyl 6-[2-amino-2-(p-hydroxyphenyl)acetamido]penicillanate, by catalytic hydrogenation in the presence of a noble metal catalyst and novel intermediates useful in preparing said compounds of formula (I).