| 摘要 |
NEW MATERIAL:The compound of formula I [R<1> is lower alkoxy, lower alkylthio, etc.; R<2> is di(lower alkyl)amino, morpholino, etc,; R<3> is H or lower alkoxycarbonyl; R<4> is lower alkylthio, halogen, etc.] or its salt. EXAMPLE:8-Chloro-4-(1-oxidothiomorpholino)-2-piperazinopyrido-[3,2-d]p yrimidine. USE:An antithrombotic agent, thrombolytic agent or their intermediate. PREPARATION:For example, a 2,4,8-trihalogenopyrido[3,2-d]pyrimidine of formula II (R<3> is alkoxycarbonyl; X is halogen) is used as a starting raw material, made to react with a dialkylamine of formula R<2>H in a solvent at -50-+50 deg.C for 10-120min and reacting the resultant compound of formula III with an alkali metal salt of a lower alkyl alcohol, etc., in a solvent.
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