| 摘要 |
NEW MATERIAL:The compound of formula I (R<1> is lower alkyl, lower alkoxy, hydroxyl, halogen, etc,; R<2> is lower alkanoyl, lower alkyl-carbamoyl, phenylcarbamoyl, etc.; R<3> is H, hydroxyl, lower alkyl, lower alkoxy, etc,; R<4> is H, group of formula II or formula III; R<5> is group of formula IV or -CH2X; R<6> and R<7> are H, lower alkyl, 3-4C cycloalkyl or R<6> and R<7> together form a group of formula V, etc,; R<8> is H, etc,; A is 1-5C lower alkyl; l is 2 or 3; m is 0 or 1; n is 0 or 1; when R<4> is H, m is 0). EXAMPLE:3-Acetyl-6-chloro-2-(2-hydroxy-5-methoxyphenyl)benzothiazoline. USE:Useful as a remedy for circulatory diseases. PREPARATION:A compound of formula I wherein m=0 and R<4>=H can be produced e.g by reacting a compound of formula VI with a compound of formula VII and reacting the reaction product with a substance having R<2>-introducing activity. |
