CEPHALOSPORIN COMPOUND FOR ORAL ADMINISTRATION

摘要

NEW MATERIAL:To compound of formula I [R1 is H or lower alkyl; R2 is lower alkyl; Y is phthalidyl or group of formula II (R3 is H or methyl; R4 is lower alkyl or lower alkoxy); excluding the case that R1 is methyl or ethyl, R2 is methyl and Y is pivaloyloxymethyl, or the case that R1, R2 and R3 are methyl and R4 is lower alkoxy] and its acid addition salt. EXAMPLE:7-[ 2-( 2-Aminothiazol-4-yl)-2-methoxyiminoacetamido ]-3-methoxymethyl-3-cephem-4-carboxylic acid pivaloyloxymethyl ester. USE:A remedy for bacteriosis for oral administration. It can be absorbed easily through the digestive tracts, and gives high blood concentration of a carboxylic acid-type compound. PREPARATION:The compound of formula I can be prepared by condensing the compound of formula III with the compound of formula IV (R5 is NH2, etc.; R6 is OH, etc.), and removing the protecting group from the reaction product.