发明名称 |
Glycerol derivatives, their preparation and their therapeutic use. |
摘要 |
<p>Glycerol derivatives having at least one heterocyclic group on the 3 or 2 position and a group of formula -Y-D-Q on the 1 position (in which Y represents oxygen, sulphur, -NR<Sup>3</Sup>-, -X-CO-R'-, -R<Sup>4</Sup>-CO-X-, -NR'-CO-, -CO-NR<Sup>3</Sup>-or -X-P-(O) (OH)-O-, where -NR<Sup>3</Sup>-is optionally protected imino, R<Sup>4</Sup> represents a direct bond or -NR<Sup>3</Sup>; and X represents oxygen or sulphur; D represents optionally substituted C<Sub>1</Sub>-C<Sub>14</Sub> alkylene; and Q represents a nitrogen-containing heterocyclic group or an amino group either of which is optionally quatemized) are PAF antagonists which may be used to treat asthma, inflammation and shock. They may be prepared by reacting a glycerol derivative having an active group at the 1-position with an appropriate compound to introduce the desired group.</p> |
申请公布号 |
EP0238202(A2) |
申请公布日期 |
1987.09.23 |
申请号 |
EP19870301283 |
申请日期 |
1987.02.13 |
申请人 |
SANKYO COMPANY LIMITED |
发明人 |
NAKAMURA, NORIO SANKYO CHEMICAL;KOIKE, HIROYUKI SANKYO CHEMICAL;OHSHIMA, TAKESHI SANKYO CHEMICAL |
分类号 |
A61K31/425;A61K31/675;A61K31/42;A61K31/426;A61K31/44;A61P7/02;A61P11/00;A61P29/00;A61P37/08;C07C41/00;C07C43/315;C07C67/00;C07C69/24;C07C69/38;C07C69/708;C07C69/716;C07C239/00;C07D261/12;C07D277/20;C07D277/34;C07D413/12;C07D413/14;C07D417/12;C07D417/14;C07D521/00;C07F9/10;C07F9/653;C07F9/6539;C07F9/6558;(IPC1-7):C07F9/65 |
主分类号 |
A61K31/425 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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