摘要 |
<p>Dihydro-1<Underline style="single">H</Underline>-pyrrolizine-3,5-(2<Underline style="single">H</Underline>,6<Underline style="single">H</Underline>)-dione is produced in higher overall yield in a process which comprises catalytically hydrogenating a lower alkyl ester of 4-(hydroxyimino)heptanedioic acid in the presence of a tri-(lower alkyl)amine, followed by cyclization of the product thus produced in the presence of a cyclizing agent such as acetic anhydride. </p> |