| 发明名称 |
A RETRO-INVERSO ANALOGUE OF THE (5-14) DECAPEPTIDE OF EQUINE ANGIOTENSINOGEN, AS A SPECIFIC RENIN INHIBITOR WITH HIGH RESISTANCE TO ENZYMATIC HYDROLYSIS |
| 摘要 |
<p>Synthesis of an anlogue of the (5-14) decapeptide of equine angiotensinogen partially retro-inverted at the Phe-Val bond, of formula:
<CHEM>
The retro-inverso analogue inhibits renin with high resistance to enzymatic degradation, and can be used in the treatment of renin-dependent hypertension.</p> |
| 申请公布号 |
EP0127234(B1) |
申请公布日期 |
1987.09.23 |
| 申请号 |
EP19840200710 |
申请日期 |
1984.05.17 |
| 申请人 |
ENI-ENTE NAZIONALE IDROCARBURI |
发明人 |
PINORI, MASSIMO;VERDINI, ANTONIO SILVIO |
| 分类号 |
C07K14/81;A61K38/00;A61K38/55;A61P43/00;C07K5/02;C07K7/02;C07K7/06;(IPC1-7):C07K7/02;C07K1/04;C07K1/06 |
主分类号 |
C07K14/81 |
| 代理机构 |
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