| 摘要 |
<p>Specific common nucleolar antigens are found in a broad range of human malignant tumor specimens and have been isolated, extracted and purifed. Monoclonal antibodies specific to one of these nucleolar antigens (p145) are harvested from mouse ascites or culture supernatant and used for detection of human cancer cells. Disclosed are (1) methods of isolating the nucleolar antigen, obtaining the antigen in substantially purifed form, producing the specific antibodies, obtaining them in substantially purified form, and using the antibodies induced by the nucleolar antigen in diagnostic procedures for detecting human cancer cells, and (2) diagnostic kits comprising specific antibodies.</p> |
