| 摘要 |
<p>NEW MATERIAL:A compound of formula I [R<1> is amino which may be protected; R<2> is H, OH-protecting group; R<3> is COOH, which may be protected, COO<->; Y formula II-IV (R<4> is lower alkyl; R<5> is H, lower alkyl) which may be substituted with hydroxyl]; n is 0, 1, when R<3> is COO<->, n is 0; when R<3> is COOH which may be protected, n is 1] and its salt. EXAMPLE:7-[2-(2-Aminothiazol-4-yl)-2-hydroxyiminoacetamide]-3-(1-methy l-1-pyr rolidinio)-methyl-3-cephem-4-carboxylate (syn-isomer). USE:Antibacterial: preventive or remedy for bacterial infection. PREPARATION:The reaction between a compound of formula V or its reactive derivative or its salt and a compound of formula IV, its reactive derivative or their salt gives the compound of formula I.</p> |
