| 摘要 |
PURPOSE:To obtain a reagent having high S/N and high measurement accuracy with a lipid having a small mol.wt. as a starting point by bringing a phospholipid and/or glycolipid having an amino group into reaction with an amino acid in which the amino group is protected by a Boc group. CONSTITUTION:The phospholipid and/or glycolipid having the amino group is brought into reaction with the amino acid in which the amino group is protected by the Boc group to introduce the amino acid residue to the amino terminal of the phospholipid and/or glycolipid having the amino group. The Boc group is then removed and a crosslinking group is introduced to the amino terminal of the amino acid residue phospholipid and/or glycolipid. Liposome is further synthesized from the crosslinking group - amino acid residue phospholipid and/or glycolipid and labeling material and at least part of antigens or antibodies are immobilized to the resultant liposome. For example, a dipalmitoyl phosphatidyl ethanolamine is used as the phospholipid and/or glycolipid having the amino group and, for example, an epsilon-aminocaproic acid is used for the amino acid.
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