(CLORO-3 PROPIONIL)-2 FLUORO-4 FENOL, PROCEDIMIENTO PARA SU PREPARACION Y APLICACION PARA LA PREPARACION DE LA FLUORO-6 CROMANOMA-4.

摘要

The compound of general formula (I): which is prepared by Friedel and Crafts acylation of 4-fluorophenol or of one of its ethers, by means of 3-chloropropionyl chloride or else by a Fries rearrangement reaction of 4-fluorophenyl 3-chloropropionate. Application to the preparation of 6-fluoro-4-chromanone of general formula (II): by ring closure of 2-(3-chloropropionyl)-4-fluorophenol at room temperature or merely by heating.