| 摘要 |
NEW MATERIAL:An optically active compound expressed by formula I (mark ¦indicates asymmetric carbon; R<1> is 3-8C alkyl or phenyl; R<2> is H or lower alkyl or R<1> and R<2> together form a 5-membered ring) and an acid addition salt thereof. EXAMPLE:(S)-2-Amino-3-methyl-1-phenylbutan-1-one hydrochloride. USE:Useful as an intermediate for producing medicines and agricultural chemicals, e.g. compounds expressed by formula II (R<3> and R<4> are lower alkyl or together form 5--7-membered ring; n is 2 or 3), etc., having glutamic acid blocking action or central muscle relaxant action or as a starting raw material for optical active beta-aminoalcohols, expressed by formula III and used as an optical resolving agent. PREPARATION:An optically active amino acid expressed by formula IV as a raw material is converted into an acid addition salt of an optically active alpha-amino acid halide expressed by formula V (X is halogen), which is subjected to the Friedel-Crafts reaction with benzene in the presence of a Lewis acid, e.g. AlCl3, etc., to afford the aimed compound expressed by formula I. |
